Diagnosis: Skin Cancer Syndromes
Description: Trichilemmoma - Downward proliferation of sheets or strands of pale glycogenated cells with mild peripheral palisading and thickened basement membrane.Sometimes desmoplasia and mucin deposition. Overlying papillomatous epidermal change
Clinical Features: Papules
Pathology/Site Features: Face papules multiple
Sex: M
Age: 65
Submitted By: Ian McColl
Differential Diagnosis
History:
Adnexal Tumours associated with Syndromes Another reason why it is important to correctly identify these adnexal tumours is their association with underlying cancer syndromes. The three commonest that we see clinically are listed below with their associated adnexal tumours.
Muir Torre - Sebaceous adenomas and Sebaceous carcinoma - Gut polyps and carcinoma Dermnet Clinical Muir Torre
Cowdens Syndrome - Trichilemmomas, Tumour of follicular infundibulum - Breast, Gut and thyroid cancers Dermnet Cowden's Clinical
Birt Hogg Dube - Perifollicular fibromas, Trichodiscomas, Fibrofolliculoma - AD Tendency to Renal carcinoma and pulmonary cysts leading to pneumothorax. Dermnet Clinical Birt Hogg Dube syndrome
Gardners syndrome Hybrid cysts such as a cyst with epidermoid and pilomatricoma features should make you think of Gardners syndrome with gut polyps and carcinoma.