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Image Number #779 (Linear IgA disease)

Diagnosis: Linear IgA disease

Description: Intact blisters on the leg

Clinical Features: Blisters

Pathology/Site Features: Leg

Sex: F

Age: 76

Submitted By: Ian McColl

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Differential Diagnosis
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History: 1929bb This elderly lady has been on high dose IV antibiotics for an infected hip prosthesis when she developed this blistering eruption. Clinically Vancomycin induced linear IgA disease. DD Bullous pemphigoid or another blistering drug eruption

Description: Neutrophils in papillary dermis

Comments:Sections show a subepidermal blister with neutrophils and a few eosinophils in the base. The neutrophils extend sideways beyond the blister in the papillary dermis. The light microscopy suggests linear IgA disease. The I.F. shows +++ linear IgA along the basement membrane.

DermNetNZ   eMedicine   PubMed   Dermatology Online   Archives   JAAD for "Linear IgA disease"

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