Diagnosis: Juvenile Xanthogranuloma
Description: Admixed with histiocytes are quite frequent Touton giant cells. In addition a number of lymphocytes and eosinophils are admixed with the histiocytes.
Clinical Features: Nodule pink
Pathology/Site Features: Tumour cells in dermis
Sex: M
Age: 1
Submitted By: Ian McColl
Differential DiagnosisHistory: 5386mw 4 month old child who was born with the lower nodule.It has doubled in size and the upper lesion has recently formed. No blistering on rubbing. DD Xanthogranuloma, Mastocytoma. Punch biopsy through centre of lower nodule.
Description: Touton giant cell
Comments: There is a dense infiltrate of histiocytes completely replacing the dermis. These are plump and vary from spindle shaped to round. Some of these histiocytes have foamy cytoplasm. Admixed with histiocytes are quite frequent Touton giant cells. In addition a number of lymphocytes and eosinophils are admixed with the histiocytes. The features present are those of a juvenile xanthogranuloma.