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Image Number #755 (Juvenile Xanthogranuloma)

Diagnosis: Juvenile Xanthogranuloma

Description: Pink nodule present at birth

Clinical Features: Nodule pink

Pathology/Site Features: Abdomen

Sex: M

Age: 1

Submitted By: Ian McColl

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Differential Diagnosis
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History: 5386mw 4 month old child who was born with the lower nodule.It has doubled in size and the upper lesion has recently formed. No blistering on rubbing. DD Xanthogranuloma, Mastocytoma. Punch biopsy through centre of lower nodule.

Description: Touton giant cell

Comments: There is a dense infiltrate of histiocytes completely replacing the dermis. These are plump and vary from spindle shaped to round. Some of these histiocytes have foamy cytoplasm. Admixed with histiocytes are quite frequent Touton giant cells. In addition a number of lymphocytes and eosinophils are admixed with the histiocytes. The features present are those of a juvenile xanthogranuloma.

DermNetNZ   eMedicine   PubMed   Dermatology Online   Archives   JAAD for "Juvenile Xanthogranuloma"

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