The combination of site and the nature of the cellular infiltrate determine the diseases to be considered.
Subcorneal vesicles- Bulous impetigo,Miliaria crystallina,Staph scalded skin syndrome,Pemphigus foliaceus and erythematosus,Erythema toxicum neonatorum
Intraepidermal vesicles due to epidermal degeneration- Friction blister,Epidermolytic hyperkeratosis
Spongiotic vesicles- Eczema,Contact dermatitis,Arthropod bites
Ballooning Degeneration- Herpes simplex,Zoster and Varicella
Acantholysis- Darier's disease,Hailey-Hailey disease,Pemphigus,Grovers,Herpes virus