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Image Number #45 (Xanthogranuloma)

Diagnosis: Xanthogranuloma

Description: Dense dermal infiltrate of foamy histiocytes with some lymphocytes and eosinophils

Clinical Features: Nodule

Pathology/Site Features: Foam cells

Sex: M

Age: 0.3

Submitted By: Ian McColl

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Differential Diagnosis
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History:

4 month old child who was born with the lower nodule.It has doubled in size and the upper lesion has recently formed.No blistering on rubbing.DD Xanthogranuloma,Mastocytoma.Punch biopsy through centre of lower nodule.

Pathology Description    There is a dense infiltrate of histiocytes completely replacing the dermis. These are plump and vary from spindle shaped to round. Some of these histiocytes have foamy cytoplasm. Admixed with histiocytes are quite frequent Touton giant cells. In addition a number of lymphocytes and eosinophils are admixed with the histiocytes. The features present are those of a juvenile xanthogranuloma.

DermNetNZ   eMedicine   PubMed   Dermatology Online   Archives   JAAD for "Xanthogranuloma"

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